Endocrine Abstracts

Background: Persistent/recurrent disease in the neck is frequent in patients with papillary thyroid cancer. The main goal of this study was to evaluate the efficacy of the reoperation and radioiodine (RAI) treatment for persistent/recurrent disease after the initial treatment. Patients and Methods: A total of 30 patients (13 M/17 F) with papillary thyroid cancer were enrolled in this study. Seven cases (23.3%) had an aggressive subtype of papillary carcinoma. All had been subm...

Background: Subclinical Cushing disease is defined by mild hypercortisolism that results from a corticotroph pituitary adenoma, without any typical sign of the disease. The patients often have coexisting metabolic diseases such as diabetes mellitus, and hypertension. Conversely, silent corticotroph adenomas demonstrate normal cortisol secretion, but positive immunochemistry for ACTH, most usually without ACTH hypersecretion, although they and can progress to clinical Cushing d...

Objectives: Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affects the bones. The underlying mechanism is usually a disorder of connective tissue due to lack of type I collagen. Usually, the disease is due to mutations in the COL1A1 or COL1A2 genes. The disease is inherited in an autosomal dominant manner or occurs via a de novo mutation. There are eight types of the disease. Type I is the most common and the least sever type and is due to mutation in...

Objectives: Neurofibromatosis type 1 (NF1) is an autosomal, dominant, genetic disorder. The genetic lesion in neurofibromatosis type 1 is located at locus 17q11.2 that harbors the neurofibromin gene. Patients have 3-4 times higher possibility to develop malignancies relative to the general population. The endocrine manifestations of neurofibromatosis include precocious puberty, short stature, osteoporosis and pheochromocytoma. We present a patient with neurofibromatosis type 1...

Objectives: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules. The Bethesda System (B) classifies thyroid cytological patterns into six categories (B1-6) according to risk for malignancy.Methods: A total of 1113 patients (210 males/903 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.2±21.6 years±S.D. We correlated the demographic profile (age and ...

Introduction: Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine and nervous systems. They most commonly occur in the intestine and are graded histologically according to markers of cellular proliferation. G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) – formerly called carcinoid tumors. G3 neoplasms are called neuroendocrine carcinomas (NECs).Objectives: We present a case of a patient with ...

Objectives: Overall, papillary and follicular carcinoma is associated with a 30-year cancer-related death rate of 6 and 15%, respectively. Poorer outcomes have been associated with older age, male gender, tumor size, grade and extrathyroidal extension. We investigated the clinical and laboratory characteristics of 40 patients who presented recurrence of thyroid disease.Patients data: • 40 Patients (21 Females and 19 males) with papillary thyroid can...